
Dotarem® by Guerbet, a flagship brand with over 30 years of real-world experience.1,2
Due to its chemical structure, Dotarem® offers high thermodynamic and kinetic stability to minimize the risk of free gadolinium (Gd3+) released. 7,8
Due to its chemical structure, Dotarem® offers high thermodynamic and kinetic stability to minimize the risk of free gadolinium (Gd3+) released. 7,8
Dotarem® by Guerbet has been trusted for clinical use by radiologists for over 30 years** and is known for high molecular stability.7 With more than 140 million global doses administered,12 Dotarem delivers an effective contrast-enhanced MR examination with dependable consistency.2
Driven by its commitment to advance radiology, Guerbet Diagnostic Imaging has designed a comprehensive and complete portfolio of products and solutions for diagnostic imaging.
Diagnostic Imaging Solutions for RadiologyReferences
WARNING: RISK ASSOCIATED WITH INTRATHECAL USE and NEPHROGENIC SYSTEMIC FIBROSIS (NSF)
Risk Associated with Intrathecal Use Intrathecal administration of gadolinium-based contrast agents (GBCAs) can cause serious adverse reactions including death, coma, encephalopathy, and seizures. DOTAREM is not approved for intrathecal use.
Nephrogenic Systemic Fibrosis GBCAs increase the risk for NSF among patients with impaired elimination of the drugs. Avoid use of DOTAREM in these patients unless the diagnostic information is essential and not available with non-contrasted MRI or other modalities. NSF may result in fatal or debilitating fibrosis affecting the skin, muscle and internal organs. The risk for NSF appears highest among patients with:
Screen patients for acute kidney injury and other conditions that may reduce renal function. For patients at risk for chronically reduced renal function (e.g. age > 60 years, hypertension, diabetes), estimate the glomerular filtration rate (GFR) through laboratory testing. For patients at highest risk for NSF, do not exceed the recommended DOTAREM dose and allow a sufficient period of time for elimination of the drug from the body prior to any re-administration. |
DOTAREM® (gadoterate meglumine) injection is a prescription gadolinium-based contrast agent indicated for intravenous use with magnetic resonance imaging (MRI) in brain (intracranial), spine and associated tissues in adult and pediatric patients (including term neonates) to detect and visualize areas with disruption of the blood brain barrier (BBB) and/or abnormal vascularity.
History of clinically important hypersensitivity reactions to DOTAREM.
0.01 to 0.04% of the maternal gadolinium dose is present in breast milk.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
Please see the full Prescribing Information, including the Medication Guide, for additional important safety information.